Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
9
We aimed to understand how vitamin D3 supplementation might help adolescents suffering from irritable bowel syndrome (IBS), especially those who are deficient in vitamin D. Our study involved 112 adolescents diagnosed with IBS, who were split into two groups based on their age and gender.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
Read More
9
We conducted a randomized, double-blind clinical trial to understand how vitamin D3 affects individuals with irritable bowel syndrome (IBS). Our study involved 90 IBS patients who received either 50,000 IU of vitamin D3 or a placebo every two weeks for six months. Throughout this period, participants tracked their symptoms and completed questionnaires about their quality of life related to their IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
Read More
8
We explored the potential of high-dose vitamin D3 as a treatment for irritable bowel syndrome (IBS), a condition that significantly affects the quality of life for those who suffer from it. Our examination began with a compelling case of a 41-year-old woman who reported substantial improvements in her IBS symptoms after starting vitamin D3 supplementation.
Inspired by her experience, we gathered data from various social media platforms, where we found additional patient accounts regarding the effects of vitamin D on IBS. Our systematic analysis revealed that among 37 individuals discussing their outcomes, about 70% indicated that high-dose vitamin D supplementation helped alleviate their IBS symptoms.
While these findings suggest a positive response to vitamin D3, they highlight the need for more rigorous research. A randomised controlled trial could help confirm these observations and provide more concrete evidence on how vitamin D supplementation influences symptomatology in IBS patients.
Inspired by her experience, we gathered data from various social media platforms, where we found additional patient accounts regarding the effects of vitamin D on IBS. Our systematic analysis revealed that among 37 individuals discussing their outcomes, about 70% indicated that high-dose vitamin D supplementation helped alleviate their IBS symptoms.
While these findings suggest a positive response to vitamin D3, they highlight the need for more rigorous research. A randomised controlled trial could help confirm these observations and provide more concrete evidence on how vitamin D supplementation influences symptomatology in IBS patients.
Read More
Most Useful Reviews
9
Relieves joint fragility
I consistently use magnesium for restless legs syndrome, and this form has also alleviated joint fragility. I experienced a rapid effect without the laxative impact typically associated with magnesium on stools.
Read More
7.5
Improved bowel function
Excellent quality product. The ingredients are well chosen, and I experienced no allergic reactions. The packaging is large enough to last a long time, and the medium-sized capsules have a neutral taste. It arrived promptly and undamaged. The composition includes only beneficial and natural ingredients, including folic acid. I've noticed improvement in my bowel function and metabolism, and the first results were evident after a week of use. My nervous system also seems to function better, making me feel less anxious. I have no doubts about the effectiveness of this vitamin. Just be sure to check the dosage according to your age.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.5
- All Researches
9
We aimed to understand how vitamin D3 supplementation might help adolescents suffering from irritable bowel syndrome (IBS), especially those who are deficient in vitamin D. Our study involved 112 adolescents diagnosed with IBS, who were split into two groups based on their age and gender.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
Read More
9
We conducted a randomized, double-blind clinical trial to understand how vitamin D3 affects individuals with irritable bowel syndrome (IBS). Our study involved 90 IBS patients who received either 50,000 IU of vitamin D3 or a placebo every two weeks for six months. Throughout this period, participants tracked their symptoms and completed questionnaires about their quality of life related to their IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
The results were quite promising. We observed that those taking vitamin D3 reported significantly greater improvements in symptoms like abdominal pain, bloating, and gas compared to those receiving a placebo. Specifically, the scores evaluating the severity of IBS symptoms and the quality of life showed notable enhancements in the vitamin D group after the six-month treatment period.
This suggests that vitamin D has the potential not only to alleviate some uncomfortable IBS symptoms but also to improve overall quality of life for those affected. Our findings indicate that incorporating vitamin D3 could be a beneficial approach for managing IBS.
Read More
9
We conducted a double-blind, randomized clinical trial involving 76 patients diagnosed with diarrhea-predominant irritable bowel syndrome (IBS) to evaluate the effectiveness of a dried extract combined with calcium treatment. Participants were split into two groups: one receiving a placebo, and the other receiving a combination of 75 mg of the dried extract and 175 mg of dibasic calcium phosphate (calcium).
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Throughout the treatment period, we observed significant improvements in the quality of life, temperament, and various IBS symptoms among those who received the active treatment. Even four weeks after the treatment ended, there was a slight decrease in these benefits but still indicated some level of effectiveness.
Overall, we found that the whole extract, supplemented with calcium, helped to moderate symptoms of IBS and improve patients' overall quality of life. However, it’s important to note that due to the calcium's inclusion as part of the formulation, we can't define its isolated effect on IBS conclusively.
Read More
8
We explored the effects of a novel form of Vitamin D3, known as VitD3-NS, on individuals suffering from irritable bowel syndrome (IBS). This Vitamin D3 was complexed within cyclodextrin nanosponges to enhance its solubility and stability, which is vital because these properties can significantly affect the vitamin's biological activity.
Our study examined how VitD3-NS interacts with both healthy and IBS-affected gut-brain axes. We observed that this innovative formulation was effective in mitigating damage caused by liposaccharides, a common inflammatory factor, in the gut. Specifically, when tested at a concentration of 100 ng/mL for 48 hours, VitD3-NS helped restore the viability and integrity of crucial cells called tight junctions. It also reduced markers of oxidative stress, such as reactive oxygen species and cytokines.
Following intestinal transit, we noticed improvements in neurodegenerative conditions for both healthy individuals and those with IBS. This suggests that the protective benefits of VitD3-NS are preserved even under challenging IBS conditions, boosting its efficacy by approximately 50%. Consequently, our findings indicate that this form of Vitamin D3 could provide significant support for gut health and overall well-being for those dealing with IBS.
Our study examined how VitD3-NS interacts with both healthy and IBS-affected gut-brain axes. We observed that this innovative formulation was effective in mitigating damage caused by liposaccharides, a common inflammatory factor, in the gut. Specifically, when tested at a concentration of 100 ng/mL for 48 hours, VitD3-NS helped restore the viability and integrity of crucial cells called tight junctions. It also reduced markers of oxidative stress, such as reactive oxygen species and cytokines.
Following intestinal transit, we noticed improvements in neurodegenerative conditions for both healthy individuals and those with IBS. This suggests that the protective benefits of VitD3-NS are preserved even under challenging IBS conditions, boosting its efficacy by approximately 50%. Consequently, our findings indicate that this form of Vitamin D3 could provide significant support for gut health and overall well-being for those dealing with IBS.
Read More
Exploring the impact of stress on irritable bowel syndrome (IBS), we investigated how vitamin D3 influences stress-induced colitis in Wistar rats. The study involved four groups: a control group, a group exposed to chronic stress, and two groups treated with vitamin D3 or lactoferrin after stress exposure.
We observed that both vitamin D3 and lactoferrin treatment showed positive effects. Specifically, rats receiving vitamin D3 experienced improvements in social interactions, reduced anxiety levels, and decreased inflammation markers compared to those that were only stressed. The treatment enhanced certain beneficial proteins related to autophagy, which is the process of clearing out damaged cells and maintaining healthy cell function.
Our findings suggest that vitamin D3 might play a role in supporting gut health and mitigating symptoms associated with IBS when faced with psychological stress. However, we noted that lactoferrin appeared to provide even greater benefits in this context, indicating it could be a more effective option for managing stress-induced colitis.
Overall, this research highlights the potential of vitamin D3 as a helpful supplement for those struggling with IBS, especially in stressful situations, while also recognizing the advantages of lactoferrin.
We observed that both vitamin D3 and lactoferrin treatment showed positive effects. Specifically, rats receiving vitamin D3 experienced improvements in social interactions, reduced anxiety levels, and decreased inflammation markers compared to those that were only stressed. The treatment enhanced certain beneficial proteins related to autophagy, which is the process of clearing out damaged cells and maintaining healthy cell function.
Our findings suggest that vitamin D3 might play a role in supporting gut health and mitigating symptoms associated with IBS when faced with psychological stress. However, we noted that lactoferrin appeared to provide even greater benefits in this context, indicating it could be a more effective option for managing stress-induced colitis.
Overall, this research highlights the potential of vitamin D3 as a helpful supplement for those struggling with IBS, especially in stressful situations, while also recognizing the advantages of lactoferrin.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieves joint fragility
I consistently use magnesium for restless legs syndrome, and this form has also alleviated joint fragility. I experienced a rapid effect without the laxative impact typically associated with magnesium on stools.
Read More
7.5
Improved bowel function
Excellent quality product. The ingredients are well chosen, and I experienced no allergic reactions. The packaging is large enough to last a long time, and the medium-sized capsules have a neutral taste. It arrived promptly and undamaged. The composition includes only beneficial and natural ingredients, including folic acid. I've noticed improvement in my bowel function and metabolism, and the first results were evident after a week of use. My nervous system also seems to function better, making me feel less anxious. I have no doubts about the effectiveness of this vitamin. Just be sure to check the dosage according to your age.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Uberti F, Trotta F, Cavalli R, Galla R, Caldera F, et al. Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut-Brain Axes in Physiology and IBS Syndrome. Int J Mol Sci. 2024;25. 10.3390/ijms25042189
- Abdelmalak MFL, Abdelrahim DS, George Michael TMA, Abdel-Maksoud OM, Labib JMW. Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy. Cell Biochem Funct. 2023;41:211. 10.1002/cbf.3774
- Williams CE, Williams EA, Corfe BM. Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial. Eur J Nutr. 2022;61:299. 10.1007/s00394-021-02633-w
- Khalighi Sikaroudi M, Mokhtare M, Shidfar F, Janani L, Faghihi Kashani A, et al. Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial. EXCLI J. 2020;19:652. 10.17179/excli2020-2247
- Khalighi Sikaroudi M, Mokhtare M, Janani L, Faghihi Kashani AH, Masoodi M, et al. Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial. Complement Med Res. 2020;27:302. 10.1159/000506149
- Jalili M, Vahedi H, Poustchi H, Hekmatdoost A. Soy isoflavones and cholecalciferol reduce inflammation, and gut permeability, without any effect on antioxidant capacity in irritable bowel syndrome: A randomized clinical trial. Clin Nutr ESPEN. 2019;34:50. 10.1016/j.clnesp.2019.09.003
- Abbasnezhad A, Amani R, Hasanvand A, Yousefi Rad E, Alipour M, et al. Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome. J Am Coll Nutr. 2019;38:327. 10.1080/07315724.2018.1510349
- Amani R, Abbasnezhad A, Hajiani E, Cheraghian B, Abdoli Z, et al. Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome. Iran J Immunol. 2018;15:186. 10.22034/IJI.2018.39388
- El Amrousy D, Hassan S, El Ashry H, Yousef M, Hodeib H. Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial. Saudi J Gastroenterol. 2018;24:109. 10.4103/sjg.SJG_438_17
- Abbasnezhad A, Amani R, Hajiani E, Alavinejad P, Cheraghian B, et al. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial. Neurogastroenterol Motil. 2016;28:1533. 10.1111/nmo.12851
- Sprake EF, Grant VA, Corfe BM. Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centred data. BMJ Case Rep. 2012;2012. 10.1136/bcr-2012-007223
- Heydari P, Ghanadian M, Asghari G, Azimi M, Babaeian M, et al. A double-blind randomized clinical trial of Boiss. in the patients with diarrhea-predominant irritable bowel syndrome. Res Pharm Sci. 2023;18:89. 10.4103/1735-5362.363599
- Harvey RF, Read AE. Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome. Gut. 1973;14:983.
